We offer a Postdoctoral Position at the Structural Biology of Genomic Macromolecular Complexes lab, led by Dr. Guillermo Abascal Palacios at Instituto Biofisika (UPV/EHU-CSIC, Leioa). The maximum duration of the contract will be until June 2026. This contract is supported by CNS2023-144406, funded by MICIU/AEI /10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”.
The Structural Biology of Genomic Macromolecular Complexes laboratory focuses on the study of protein complexes that interact with DNA/RNA, with the aim of determining the molecular mechanisms responsible for their function. To achieve this goal, we carry out a combined process that includes protein cloning and expression techniques, purification using chromatographic tools and their subsequent analysis using biophysical and structural biology methods such as cryo-electron microscopy (Cryo-EM) or X-ray crystallography.
The researcher will participate in a project aimed at understanding the relevance of mobile genetic elements in the development of amyotrophic lateral sclerosis (ALS) and other human pathologies. Instituto Biofisika (IBF) has a wide variety of technical and scientific equipment, which will be at the disposal of the researcher, including the first Titan Krios G4 cryo-electron microscope in Spain, which allows the determination of atomic structures at an unprecedented level.