March, Thu 26, 2026, 12:00h
Integrative structural biology of a T=219 marine giant virus
Sara Otaegi (CNB-CSIC, Madrid)
Bilbao Biophysics Discussion Group Seminar
“Integrative structural biology of a T=219 marine giant virus”
Sara Otaegi, CNB-CSIC, Madrid.
Date: March 26, 2026, at 12:00.
Location: Félix M. Goñi Atrium, Instituto Biofisika.
Abstract
Giant viruses possess unusually large particles and genomes. The seminar presents an integrative study of the marine giant virus PkV-RF02, whose linear double-stranded DNA genome is about 583 kilobases and whose capsid is roughly 200 nanometres in diameter.
High-resolution cryo-electron microscopy and cross-linking mass spectrometry were combined to map the viral architecture and protein–protein interactions. The analysis helps assign functions to structural components, many of which remain poorly characterised.
